The IDF on Saturday said it was imposing a total closure on Judea and Samaria which will last until Monday night, ahead of the Jewish holiday of Simchat Torah.
Tens of thousands of Arabs will not be able to cross into Israel as a result of the measure, which will be in place from midnight Saturday until midnight Monday.
Similar closures have been placed on Judea and Samaria in the past during Jewish holidays, particularly Yom Kippur and Passover. Those holidays are often associated with increased tension and potential for violence and terror attacks, particularly around religious sites which see increased numbers of Jewish visitors arriving to worship.
The crossings on the Gaza border have also been closed off for the holiday period, the army said, although exceptions are expected to be made for special humanitarian and medical cases.
Arab terrorists since October 2015 have killed 36 Israelis, two Americans, one Jordanian, an Eritrean and a Sudanese national.
At least 234 Arab terrorists were eliminated while carrying out terror attacks.
On Thursday an Arab teen-terrorist throwing rocks at patrolling Israeli soldiers was shot dead next to Beit Ummar near the city of Hevron.
One soldier was lightly wounded by the rocks hurled by the 15-year-old jihadist.
The incident occurred a day after a female Arab terrorist approached border police with a knife at a Gush Etzion junction and was shot and eliminated.