An explosion has ripped through Manhattan leaving more than a dozen people injured on Saturday night.

The blast at 23rd Street and Sixth Avenue in Chelsea around 8.30pm is thought to have come from a dumpster and could have come from an explosive device.

The Fire Department reported that there were at least 25 people injured in the blast, but their injuries don’t appear life-threatening.

The NYPD Special Ops tweeted that they are investigating a ‘possible’ second device that was found at 27th Street and Sixth Avenue, which is just four blocks away from where the blast occurred.

It comes just hours after a pipe bomb in a trashcan blew up near a fun-run for the military in New Jersey – but no one was injured.

The victims of the explosion have been taken to several different hospitals.

The FBI and NYPD Counterterrorism Unit are investigating but there is no confirmation on what caused the blast yet.

Witness Chris Duffy tweeted a photo of a destroyed dumpster and said it was the source of the blast.

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The NYPD has taken precautions by increasing security across the city following the blast Saturday night.

President Barack Obama has been briefed on the situation following his remarks at the Black Congressional Caucus Gala.

New York Mayor Bill de Blasio is now on the scene of the blast and he’s currently being briefed on the situation.

De Blasio, Police Commissioner James P O’Neill and Fire Department Commissioner Daniel Nigro will hold a press conference regarding the explosion.

Authorities have ruled out gas as a cause for the explosion.

The blast, according to a witness, occurred on 23rd Street, a major east to west thoroughfare in the fashionable downtown neighborhood of Chelsea.

Hundreds of people were out and about in the neighborhood when the explosion occurred.

The Chelsea neighborhood is known for its nightlife fun, with its many bars and clubs that are heavily populated on the weekends.

A car seen driving through the area had its rear window blown out.

Officers with police dogs are searching the premises for any remnants of a bomb or explosive device, if there is one, authorities reported.

New York City Police issued a bulletin advising motorists in the area that they should ‘expect extensive traffic delays and emergency personnel in the area of 23rd Street and 7th Avenue’ due to police activity there and asking the public to avoid the area.

Hundreds of people were seen fleeing down the block, as police cordoned off the area.

The MTA announced that the F, M, PATH train to New Jersey, the 1 and N trains have been shut down because of the explosion.

At the scene crowds of people were seen standing around and taking photos of the scene. The area has a heavy police presence and several emergency responders.

The explosion in the Chelsea neighborhood comes just hours after the deadly pipe bomb that exploded along a route where thousands of runners were due to take part in a charity run in New Jersey.

More than one thousand spectators, including war veterans and small children, had gathered just a few blocks from the blast in Jersey Shore town on Saturday afternoon.

Two more pipe bombs, that hadn’t exploded, were found in a garbage can near the event which sought to raise money for marines and sailors.

The pipe bomb near D Street exploded about 9.30am – the exact time runners were due to pass that location.

No injuries were reported but bomb-sniffing dogs have continued to look for more bombs in the area.

Explosive experts in New York will be comparing the Manhattan explosion to the New Jersey one to see if the two have anything in common.

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